Kaplan-Meier estimates of progression-free survival as assessed by blinded central review board in the intention-to-treat population (A) and in key subgroups (B). HR values in the subgroup analysis were unstratified. CI denotes confidence interval, HR, hazard ratio, ICI immune checkpoint inhibitor, IMDC International Metastatic Renal Cell Carcinoma Database Consortium, TKI tyrosine kinase inhibitor, VEGF vascular endothelial growth factor.