TABLE 2.
Relapse‐free survival at 3, 6, and 12 months according to analytical parameters.
| Biomarker | Time | Units | N valid | N (%) | S3 | S6 | S12 | p‐value | Unadjusted HR | 95% CI |
|---|---|---|---|---|---|---|---|---|---|---|
| AST (U/L) | At first 24/48h of admission | ≤35 | 3016 | 712 (23.6) | 0.79 | 0.72 | 0.61 | 0.445 | 1 | |
| >35 | 2304 (76.4) | 0.79 | 0.71 | 0.63 | 0.94 | 0.82–1.09 | ||||
| Highest value | ≤35 | 3016 | 528 (17.5) | 0.79 | 0.73 | 0.64 | 0.779 | 1 | ||
| >35 | 2488 (82.5) | 0.79 | 0.71 | 0.63 | 1.02 | 0.87–1.20 | ||||
| At discharge | ≤35 | 2852 | 1517 (53.2) | 0.79 | 0.72 | 0.63 | 0.434 | 1 | ||
| >35 | 1335 (46.8) | 0.78 | 0.70 | 0.63 | 1.05 | 0.93–1.19 | ||||
| ALT (U/L) | At first 24/48h of admission | ≤35 | 3016 | 685 (22.7) | 0.80 | 0.73 | 0.65 | 0.494 | 1 | |
| >35 | 2331 (77.3) | 0.78 | 0.71 | 0.62 | 1.05 | 0.91–1.22 | ||||
| Highest value | ≤35 | 2812 | 481 (15.9) | 0.80 | 0.75 | 0.67 | 0.147 | 1 | ||
| >35 | 2535 (84.1) | 0.79 | 0.71 | 0.62 | 1.13 | 0.96–1.35 | ||||
| At discharge | ≤35 | 3016 | 1077 (35.7) | 0.81 | 0.73 | 0.64 | 0.278 | 1 | ||
| >35 | 1939 (64.3) | 0.78 | 0.70 | 0.62 | 1.07 | 0.94–1.22 | ||||
| GGT (U/L) | At first 24/48h of admission | ≤78 | 3016 | 616 (20.4) | 0.81 | 0.73 | 0.64 | 0.373 | 1 | |
| >78 | 2400 (79.6) | 0.78 | 0.71 | 0.62 | 1.07 | 0.92–1.25 | ||||
| Highest value | ≤78 | 3016 | 408 (13.5) | 0.82 | 0.73 | 0.66 | 0.309 | 1 | ||
| >78 | 2608 (86.5) | 0.78 | 0.71 | 0.62 | 1.10 | 0.92–1.32 | ||||
| At discharge | ≤78 | 3016 | 607 (20.1) | 0.81 | 0.72 | 0.64 | 0.499 | 1 | ||
| >78 | 2409 (79.9) | 0.78 | 0.71 | 0.62 | 1.05 | 0.90–1.23 | ||||
| ALP (U/L) | At first 24/48h of admission | ≤150 | 3016 | 1663 (55.1) | 0.78 | 0.71 | 0.63 | 0.943 | 1 | |
| >150 | 1353 (44.9) | 0.78 | 0.71 | 0.63 | 1.00 | 0.80–1.13 | ||||
| Highest value | ≤150 | 3016 | 1186 (39.3) | 0.78 | 0.71 | 0.63 | 0.493 | 1 | ||
| >150 | 1830 (60.7) | 0.79 | 0.72 | 0.63 | 0.96 | 0.84–1.09 | ||||
| At discharge | ≤150 | 3016 | 1797 (59.6) | 0.79 | 0.71 | 0.63 | 0.845 | 1 | ||
| >150 | 1219 (40.4) | 0.79 | 0.71 | 0.62 | 1.01 | 0.89–1.15 | ||||
| Bilirubin (mg/dl) | At first 24/48h of admission | ≤1.2 | 3016 | 1144 (37.9) | 0.79 | 0.70 | 0.61 | 0.113 | 1 | |
| >1.2 | 1872 (62.1) | 0.79 | 0.72 | 0.64 | 0.90 | 0.80–1.02 | ||||
| Highest value | ≤1.2 | 3016 | 1012 (33.6) | 0.79 | 0.71 | 0.61 | 0.454 | 1 | ||
| >1.2 | 2004 (66.4) | 0.79 | 0.71 | 0.64 | 0.95 | 0.84–1.08 | ||||
| At discharge | ≤1.2 | 3016 | 2300 (76.3) | 0.79 | 0.72 | 0.63 | 0.956 | 1 | ||
| >1.2 | 716 (23.7) | 0.78 | 0.69 | 0.63 | 1.00 | 0.86–1.15 | ||||
| Leukocytes (count/mm3) | At first 24/48h of admission | ≤11,000 | 3016 | 1535 (50.9) | 0.77 | 0.69 | 0.61 | 0.018 | 1 | |
| >11,000 | 1481 (49.1) | 0.81 | 0.74 | 0.65 | 0.86 | 0.76–0.98 | ||||
| Highest value | ≤11,000 | 3016 | 1288 (42.7) | 0.76 | 0.67 | 0.59 | <0.001 | 1 | ||
| >11,000 | 1728 (57.3) | 0.81 | 0.75 | 0.66 | 0.78 | 0.69–0.88 | ||||
| At discharge | ≤11,000 | 3016 | 2668 (88.5) | 0.79 | 0.71 | 0.62 | 0.655 | 1 | ||
| >11,000 | 348 (11.5) | 0.79 | 0.75 | 0.68 | 0.97 | 0.79–1.16 | ||||
| Neutrophils (count/mm3) | At first 24/48h of admission | ≤8500 | 3016 | 1421 (47.1) | 0.77 | 0.69 | 0.61 | 0.004 | 1 | |
| >8500 | 1595 (52.9) | 0.80 | 0.73 | 0.65 | 0.88 | 0.78–0.99 | ||||
| Highest value | ≤8500 | 3016 | 1193 (39.6) | 0.76 | 0.67 | 0.59 | <0.001 | 1 | ||
| >8500 | 1823 (60.4) | 0.81 | 0.74 | 0.66 | 0.78 | 0.69–0.89 | ||||
| At discharge | ≤8500 | 3016 | 2744 (91.0) | 0.79 | 0.71 | 0.63 | 0.911 | 1 | ||
| >8500 | 272 (9.0) | 0.78 | 0.73 | 0.66 | 0.98 | 0.80–1.23 | ||||
| Lymphocytes (count/mm3) | At first 24/48h of admission | ≤4500 | 3016 | 2989 (99.1) | 0.79 | 0.71 | 0.63 | 0.865 | 1 | |
| >4500 | 27 (0.9) | 0.76 | 0.69 | 0.69 | 0.94 | 0.45–1.98 | ||||
| Highest value | ≤4500 | 3016 | 2984 (98.9) | 0.79 | 0.71 | 0.63 | 0.492 | 1 | ||
| >4500 | 32 (1.1) | 0.84 | 0.74 | 0.67 | 0.78 | 0.39–1.57 | ||||
| At discharge | ≤4500 | 3016 | 3001 (99.5) | 0.79 | 0.71 | 0.63 | 0.964 | 1 | ||
| >4500 | 15 (0.5) | 0.86 | 0.66 | 0.55 | 1.02 | 0.42–2.46 | ||||
| Hematocrit (%) | At first 24/48h of admission | ≤47 F/51 M | 3016 | 2920 (96.8) | 0.79 | 0.71 | 0.63 | 0.392 | 1 | |
| ≤47 F/51 M | 96 (3.2) | 0.74 | 0.66 | 0.58 | 1.16 | 0.83–1.61 | ||||
| Highest value | ≤47 F/51 M | 3016 | 2898 (96.1) | 0.79 | 0.71 | 0.63 | 0.361 | 1 | ||
| ≤47 F/51 M | 118 (3.9) | 0.74 | 0.66 | 0.60 | 1.15 | 0.85–1.55 | ||||
| At discharge | ≤47 F/51 M | 3016 | 2993 (99.2) | 0.79 | 0.71 | 0.63 | 0.023 | 1 | ||
| ≤47 F/51 M | 23 (0.8) | 0.53 | 0.47 | 0.47 | 1.96 | 1.08–3.55 | ||||
| Urea (mg/L) | At first 24/48h of admission | ≤54 | 3016 | 2319 (76.9) | 0.78 | 0.70 | 0.62 | 0.008 | 1 | |
| >54 | 697 (23.1) | 0.82 | 0.76 | 0.65 | 0.82 | 0.70–0.95 | ||||
| Highest value | ≤54 | 3016 | 2089 (69.3) | 0.77 | 0.69 | 0.61 | <0.001 | 1 | ||
| >54 | 927 (30.7) | 0.83 | 0.77 | 0.68 | 0.75 | 0.65–0.85 | ||||
| At discharge | ≤54 | 3016 | 2602 (86.3) | 0.78 | 0.71 | 0.62 | 0.060 | 1 | ||
| >54 | 414 (13.7) | 0.83 | 0.78 | 0.67 | 0.82 | 0.67–1.01 | ||||
| CRP (mg/L) | At first 24/48h of admission | ≤5 | 3016 | 537 (17.8) | 0.75 | 0.68 | 0.58 | 0.019 | 1 | |
| >5 | 2479 (82.2) | 0.80 | 0.72 | 0.64 | 0.83 | 0.71–0.97 | ||||
| Highest value | ≤5 | 3016 | 144 (4.8) | 0.75 | 0.70 | 0.59 | 0.266 | 1 | ||
| >5 | 2872 (95.2) | 0.79 | 0.71 | 0.63 | 0.85 | 0.64–1.13 | ||||
| At discharge | ≤5 | 3016 | 361 (12.0) | 0.76 | 0.67 | 0.59 | 0.122 | 1 | ||
| >5 | 2655 (88.0) | 0.79 | 0.72 | 0.63 | 0.87 | 0.72–1.04 |
Note: N = 3016. Data presented as: n (%).
Abbreviations: ALP, Alkaline Phosphatase; ALT, Alanine Aminotransferase; AST, Aspartate Aminotransferase; CI, Confidence Interval; CRP, C‐Reactive protein; F, female; GGT, Gamma Glutamyl Transferase; HR, Hazard Ratio; M, male.