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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: Clin Cancer Res. 2023 Nov 1;29(21):4464–4478. doi: 10.1158/1078-0432.CCR-23-1439

Fig. 1. Upregulation of TNF-α-STING-NF-κB and non-canonical STING-NF-κB gene expression in SPOP mutant prostate cancer patients.

Fig. 1.

A. GSEA analysis of castration-resistant prostate cancer data sets (Beltran, CRPC-Adeno and CRPC-Neuro; Robinson-total RNA; Robinson- polyA RNA) with a curated gene set (Hallmark) shows enrichment of TNF-α-NFκB signaling genes. B. Heatmap of significantly differentially regulated genes from unsupervised analysis of the same data set using a 259 gene set comprised of canonical cGAS-STING-TBK1 and NF-κB signaling genes identified a cluster of differentially expressed genes in SPOPmut prostate cancer patients compared to SPOP wild-type patients. C. “Immunome” analysis of Beltran CRPC cohort using a compendium of publicly available data from purified immune subsets. D. Heatmap of significantly upregulated genes in SPOPmut prostate cancer from Beltran dataset in B (NC-STING signature genes) using TCGA SPOPmut data set ordered by the z-score of NC-STING signature (NC-STING Score).