Figure 2.

Associations of acetaminophen use during pregnancy and Attention Problems scores on the CBCL at 2 (left panel), 3 (middle panel), and 4 years of age (right panel).^a At 2 years of age, higher acetaminophen exposure during the second trimester (β=0.009, 95% CI: 0.003, 0.015) and throughout pregnancy (β=0.004, 95% CI: 0.001, 0.008) were related to higher Attention Problems scores. Higher acetaminophen exposure during the second trimester (β=0.009, 95% CI: 0.004, 0.014) and throughout pregnancy (β=0.004, 95% CI: 0.001, 0.007) were also associated with higher Attention Problems scores at 3 years of age.

^aAll models were adjusted for child sex, age at assessment, and gestational age, maternal age, maternal parity (nulliparous vs. ≥1), maternal education (<bachelor’s degree vs. ≥bachelor’s degree), mean perceived stress score during pregnancy, mean Edinburgh Postnatal Depression Scale score during pregnancy, and indication (N/A, pain, other, or multiple).

*p < 0.05, **p < 0.01