Associations of acetaminophen use during pregnancy and Internalizing Behavior scores on the CBCL at ages 2 (left panel), 3 (middle panel), and 4 (right panel).a Higher acetaminophen exposure during the first trimester was associated with lower Internalizing Behavior scores (β=−0.021, 95% CI: −0.045, 0.002).
aAll models were adjusted for child sex, age at assessment, and gestational age, maternal age, maternal parity (nulliparous vs. ≥1), maternal education (<bachelor’s degree vs. ≥bachelor’s degree), mean perceived stress score during pregnancy, mean Edinburgh Postnatal Depression Scale score during pregnancy, and indication (N/A, pain, other, or multiple).
# p < 0.10