Table 2. CHESS II demographics by disease severity and treatment regimen.
| Severity | Total ( N = 468) |
||||
|---|---|---|---|---|---|
| Moderate ( n = 190) |
Severe ( n = 278) |
||||
| Prophylaxis ( n = 16) |
Other ( n = 174) |
Prophylaxis ( n = 157) |
Other ( n = 121) |
||
| Age | |||||
| Mean (SD) | 42.4 (16.9) | 39.6 (14.6) | 38.7 (14.0) | 37.0 (12.4) | 38.7 (13.9) |
| Median (IQR) | 45.5 (29.5) | 38 (21) | 38 (22) | 36 (17) | 37.5 (22) |
| Age category, n (%) | |||||
| 18–35 | 7 (43.8) | 77 (44.3) | 67 (42.7) | 59 (48.8) | 210 (44.9) |
| 36–59 | 7 (43.8) | 77 (44.3) | 78 (49.7) | 55 (45.5) | 217 (46.4) |
| 60+ | 2 (12.5) | 20 (11.5) | 12 (7.6) | 7 (5.8) | 41 (8.8) |
| Total | 16 (100) | 174 (100) | 157 (100) | 121 (100) | 468 (100) |
| Treatment type, n (%) | |||||
| EHL FVIII | 1 (6.3) | 9 (5.2) | 24 (15.3) | 18 (14.9) | 52 (11.1) |
| SHL or plasma-derived FVIII | 2 (12.5) | 50 (28.7) | 129 (82.2) | 102 (84.3) | 283 (60.5) |
| No FVIII administered in prior 12 mo a | 0 (0) | 115 (66.1) | 0 (0) | 0 (0) | 115 (24.6) |
| Unknown | 13 (81.3) | 0 (0) | 4 (2.5) | 1 (0.8) | 18 (3.8) |
| Country | |||||
| Germany | 0 (0.0) | 16 (9.2) | 14 (8.9) | 7 (5.8) | 37 (7.9) |
| Spain | 11 (68.8) | 53 (30.5) | 47 (29.9) | 38 (31.4) | 149 (31.8) |
| France | 0 (0.0) | 16 (9.2) | 13 (8.3) | 13 (10.7) | 42 (9.0) |
| Italy | 5 (31.3) | 68 (39.1) | 67 (42.7) | 48 (39.7) | 188 (40.2) |
| Romania | 0 (0.0) | 2 (1.2) | 0 (0.0) | 1 (0.8) | 3 (0.6) |
| Holland | 0 (0.0) | 1 (0.6) | 0 (0.0) | 0 (0.0) | 1 (0.2) |
| UK | 0 (0.0) | 18 (10.3) | 16 (10.2) | 14 (11.6) | 48 (10.3) |
Abbreviations: EHL, extended half-life; IQR, interquartile range; SD, standard deviation; SHL, standard half-life.
a
All participants who had not received FVIII in the prior 12 months had moderate hemophilia A.