Table 5. CHESS II outcomes evaluated by disease severity and treatment approach.
| Severity | Total ( N = 468) |
||||
|---|---|---|---|---|---|
| Moderate ( n = 190) |
Severe ( n = 278) |
||||
| Prophylaxis ( n = 16) |
Other ( n = 174) |
Prophylaxis ( n = 157) |
Other ( n = 121) |
||
| ABR | |||||
| n | 16 | 174 | 148 | 120 | 468 |
| Mean (SD) | 2.38 (1.82) | 2.54 (2.97) | 3.84 (3.09) | 4.02 (9.18) | 3.36 (5.33) |
| Median (IQR) | 2.0 (2.0) | 2.0 (2.0) | 3.0 (3.5) | 3.0 (3.0) | 2.0 (3.0) |
| ABR category, n (%) | |||||
| 0 | 1 (6.3) | 27 (15.5) | 12 (7.6) | 9 (7.4) | 49 (10.5) |
| 1 | 4 (25.0) | 53 (30.5) | 25 (15.9) | 24 (19.8) | 105 (22.4) |
| 2+ | 11 (68.8) | 94 (54.0) | 120 (76.4) | 88 (72.7) | 314 (67.1) |
| Target joint number category, n (%) | |||||
| None | 10 (62.5) | 135 (77.6) | 90 (57.3) | 66 (54.5) | 301 (64.3) |
| 1 target joint | 5 (31.3) | 22 (12.6) | 36 (22.9) | 28 (23.1) | 91 (19.4) |
| 2+ target joints | 1 (6.3) | 17 (9.8) | 31 (19.7) | 27 (22.3) | 76 (16.2) |
| Problem joint number category, n (%) | |||||
| None | 4 (25.0) | 112 (64.4) | 79 (50.3) | 68 (56.2) | 263 (56.2) |
| 1 problem joint | 9 (56.3) | 35 (20.1) | 41 (26.1) | 32 (16.4) | 117 (25.0) |
| 2+ problem joints | 3 (18.7) | 27 (15.5) | 37 (23.6) | 21 (17.4) | 88 (18.8) |
| Current chronic pain level, n (%) | |||||
| No pain | 3 (18.8) | 59 (33.9) | 33 (21.0) | 27 (22.3) | 122 (26.1) |
| Mild pain | 5 (31.3) | 81 (46.6) | 60 (38.2) | 43 (35.5) | 189 (40.4) |
| Moderate pain | 8 (50.0) | 31 (17.8) | 49 (31.2) | 38 (31.4) | 126 (26.9) |
| Severe pain | 0 (0.0) | 3 (1.7) | 15 (9.6) | 13 (10.7) | 31 (6.6) |
| Participants with anxiety, n (%) | 8 (50.0) | 28 (16.1) | 34 (21.7) | 16 (13.2) | 86 (18.4) |
| Participants with depression, n (%) | 3 (18.8) | 20 (11.5) | 12 (7.6) | 14 (11.6) | 49 (10.5) |
Abbreviations: ABR, annualized bleeding rate; IQR, interquartile range; SD, standard deviation.