Table 6. CHESS PAEDs outcomes evaluated by disease severity and treatment approach.
| Severity | Total ( N = 691) |
||||
|---|---|---|---|---|---|
| Moderate ( n = 282) |
Severe ( n = 409) |
||||
| Prophylaxis ( n = 136) |
Other ( n = 146) |
Prophylaxis ( n = 332) |
Other ( n = 77) |
||
| ABR | |||||
| Mean (SD) | 4.01 (9.73) | 4.32 (9.86) | 2.86 (4.93) | 4.88 (16.15) | 3.62 (8.94) |
| Median (IQR) | 1.0 (3.5) | 2.0 (5.0) | 2.0 (3.0) | 2.0 (3.0) | 2 (4) |
| ABR category, n (%) | |||||
| 0 | 43 (31.6) | 38 (26.0) | 85 (25.6) | 17 (22.1) | 183 (26.5) |
| 1 | 26 (19.1) | 33 (22.6) | 68 (20.5) | 7 (9.0) | 134 (19.4) |
| 2+ | 67 (49.3) | 75 (51.4) | 179 (53.9) | 53 (68.8) | 374 (54.1) |
| Target joint number category, n (%) | |||||
| None | 112 (82.4) | 139 (95.2) | 260 (78.3) | 65 (84.4) | 576 (83.4) |
| 1 target joint | 18 (13.2) | 6 (4.1) | 61 (18.4) | 10 (13.0) | 95 (13.7) |
| 2+ target joints | 6 (4.4) | 1 (0.7) | 11 (3.3) | 2 (2.6) | 20 (2.9) |
| Problem joint number category, n (%) | |||||
| None | 101 (74.3) | 134 (91.8) | 233 (70.2) | 64 (83.1) | 532 (77.0) |
| 1 problem joint | 22 (16.2) | 8 (5.5) | 78 (23.5) | 10 (13.0) | 118 (17.1) |
| 2+ problem joints | 13 (5.9) | 4 (2.7) | 21 (6.3) | 3 (3.9) | 41 (5.9) |
| Current chronic pain level, n (%) | |||||
| No pain | 58 (42.6) | 74 (50.7) | 126 (38.0) | 27 (35.1) | 285 (41.2) |
| Mild pain | 52 (38.2) | 64 (43.8) | 147 (44.3) | 33 (42.9) | 296 (42.8) |
| Moderate pain | 26 (19.1) | 8 (5.5) | 57 (17.2) | 17 (22.1) | 108 (15.6) |
| Severe pain | 0 (0) | 0 (0) | 2 (0.6) | 0 (0) | 2 (0.3) |
| Participants with anxiety, n (%) | 10 (7.4) | 13 (8.9) | 26 (7.8) | 7 (9.1) | 56 (8.1) |
| Participants with depression, n (%) | 3 (2.2) | 5 (3.4) | 4 (1.2) | 1 (1.3) | 13 (1.9) |
Abbreviations: ABR, annualized bleeding rate; IQR, interquartile range; SD, standard deviation.