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. 2024 Mar 28;56(4):652–662. doi: 10.1038/s41588-024-01688-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — (a) Milo cell neighbourhood differential abundance plots of the significant (FDR < 0.05) changes in the breast composition comparing average risk (AR) donors (n = 22) to the high risk BRCA1 germline (HR-BR1) cohort (n = 11), blocking for the effects of age and parity. Blue represents enrichment with HR-BR1, whilst red denotes depletion with HR-BR1. (b) Beeswarm plot of the log fold changes of the Milo neighbourhoods grouped into each cell type subcluster for AR versus HR-BR1. Neighbourhoods with a significant change in cellular abundance are coloured as indicated. (c) Milo cell neighbourhood differential abundance plots of the significant (FDR < 0.05) changes in the breast composition comparing AR donors (n = 22) to the high risk BRCA2 germline (HR-BR2) cohort (n = 11), blocking for the effects of age and parity. Blue represents enrichment with HR-BR2, whilst red denotes depletion with HR-BR2. (d) Beeswarm plot of the log fold changes of the Milo neighbourhoods grouped into each cell type subcluster for AR versus HR-BR2. Neighbourhoods with a significant change in cellular abundance are coloured as indicated.