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. 2024 Apr 15;73(6):96. doi: 10.1007/s00262-024-03678-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — CD200 expression is upregulated on iCAFs. A CD200 mRNA expression from PDAC patient PSCs compared to normal HPPFC controls via Nanostring analysis. B Western Plot showing CD200 expression in PDAC patient PSCs. C UMAP of CAF clusters from single-cell RNA-sequencing dataset of PDAC patients from NIH dbGaP and D identification of clusters as myCAFs and iCAFs. E Volcano-plot showing significantly upregulated and downregulated genes in iCAFs. F Top 10 pathways significantly affected in iCAFs via Reactome analysis. *** = p < 0.001