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. 2024 Mar 10;16(4):870–884. doi: 10.1038/s44321-024-00048-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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(A) Graph of time to matrix detachment in RDEB (n = 15, 7 biological replicates in 2–3 technical replicates) and non-EB (n = 11, 8 biological replicates in 1–2 technical replicates). Mann–Whitney test for significance. (B) Graph of time to matrix detachment in RDEB with vehicle control (n = 16, 5 biological replicates in 3–4 technical replicates) and SB431542 (n = 11, 5 biological replicates in 2–3 technical replicates). Mann–Whitney for significance. (C) Graph of time to matrix detachment in RDEB with vehicle control (n = 11, 5 biological replicates in 2–3 technical replicates) and SIS3 (n = 7, 5 biological replicates in 1–2 technical replicates). Mann–Whitney test for significance. (D) Graph of time to matrix detachment in non-EB with vehicle control (n = 41, 7 biological replicates in 6–7 technical replicates) and exogenous TGFβ1 (n = 42, 7 biological replicates in 6–7 technical replicates). Mann–Whitney test for significance. (E) Graph of RDEB (n = 4 biological replicates) and non-EB (n = 3 biological replicates) population viability over 10 days. Paired t test for significance. (F) Graph for elastic modulus of matrix in RDEB (n = 25, 7 biological replicates in 3–4 technical replicates) and non-EB (n = 45, 6 biological replicates in 7–8 technical replicates) matrix. Unpaired t test for significance. (G) Graph for elastic modulus of matrix in RDEB with vehicle control, exogenous TGFβ, and SB431542 (3 biological replicates in 12 technical replicates) treatment. Kruskal–Wallis test with Dunn’s correction for significance. (H) Graph of total hydroxyproline amount in cell layer comparing cells and matrix (n = 5 biological replicates) and matrix only (n = 5 biological replicates). Unpaired t test for significance. (I) Graph of total hydroxyproline amount (mean $\pm$ SEM) in cell layer and media of RDEB (n = 6, 3 biological replicates in duplicate), non-EB (n = 6, 3 biological replicates in duplicate), RDEB + SB431542 (n = 6, 3 biological replicates in duplicate), and non-EB + TGFβ1 (n = 6, 3 biological replicates in duplicate) treatment. Data information: In (A–H), data are presented as mean $\pm$ SEM. **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001, P > 0.05 is not significant (ns). Source data are available online for this figure.