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. 2024 Mar 13;16(4):823–853. doi: 10.1038/s44321-024-00050-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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(A) UMAP clusters of scRNA-seq datasets of primary TNBC tumors. (B) Circle plot showing number of interactions between the cell types in primary TNBC scRNA-seq dataset. (C) Cell–cell communication of the epithelial cells including basal epithelial with other cell types within TNBC spatial transcriptome dataset. The line and its width represent the strength of the cellular communications between the cell types on the histological section. (D) Circle plot showing key signaling pathways involved in intercellular communications between the basal and other cell types in TNBC. (E) Bar plot showing ligand-receptor interaction of LAMININ signaling pathway for intercellular communication in TNBC. (F, G) UMAP plot of post chemotherapy-treated chemoresistance and chemosensitive cells. (H) Bar plot showing the total number of interactions in the resistant and sensitive group of cells. (I) Circle plot showing the number of interactions between the cell types in chemosensitive and chemoresistant datasets. (J) Plot shows key signaling pathways enriched in chemoresistant and chemosensitive cells. (K) Circle plot showing the number of interactions of the intercellular signaling pathway in chemosensitive and chemoresistant cells. Source data are available online for this figure.