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. 2024 Mar 19;16(4):805–822. doi: 10.1038/s44321-024-00053-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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Ultra-tissue expansion microscopy revealed the disorganization of the KO cilium in the untreated area, whereas the co-treatment by the two isoforms restored CC structure organization in the treated area. Note that FAM161A, POC5, and CEP290 localizations are restored in the treated area but their respective labeling extends toward the apical part of the CC (orange arrows) compared to the wild type. In addition, the LCA5 labeling was not grouped, but in part dispersed (orange arrow). IFT81 was also imperfectly distributed (orange arrow) compared to the wild type. For the WT retina, FAM161A labeling from retina cryosection is hardly detectable at low magnification. Scale bar bars: 20 µm and 1 µm for low- and high magnification, respectively. ONL outer nuclear layer, CC connecting cilium. white arrows: correct labeling; orange arrows: ectopic or absence of labeling. Source data are available online for this figure.