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. 2024 Apr 2;15:1348382. doi: 10.3389/fendo.2024.1348382

Table 3.

Association of GWG below and above the optimal range in the current study with adverse pregnancy outcomes.

BMI group Outcomes Rate of outcome Risk of outcome
GWG below the optimal range GWG within the optimal range GWG above the optimal range P-value GWG below VS within the optimal range GWG above VS within the optimal range
aOR (95%CI) aOR (95%CI)
Normal weight Cesarean delivery 21 (41.18) 48 (48.98) 33 (55.93) 0.304 0.68 (0.33, 1.41) 1.26 (0.62, 2.56)
Assisted vaginal delivery 4 (7.84) 5 (5.10) 6 (10.17) 0.448a 1.42 (0.32, 6.24) 1.45 (0.38, 5.62)
Vaginal delivery 26 (50.98) 45 (45.92) 20 (33.9) 0.166 1.32 (0.64, 2.72) 0.69 (0.33, 1.44)
Gestational hypertension 3 (5.88) 8 (8.16) 9 (15.25) 0.200 0.55 (0.12, 2.51) 1.64 (0.54, 4.97)
Preeclampsia 3 (5.88) 8 (8.16) 5 (8.47) 0.892a 0.31 (0.05 1.91) 0.88 (0.25, 3.10)
PROM 14 (27.45) 31 (31.63) 12 (20.34) 0.307 0.69 (0.31, 1.52) 0.61 (0.27, 1.37)
Preterm birth 7 (13.73) 8 (8.16) 2 (3.39) 0.146a / /
Postpartum hemorrhage 6 (14.29) 14 (14.29) 6 (10.17) 0.739 0.76 (0.26, 2.27) 0.57 (0.19, 1.70)
Macrosomia 1 (1.96) 11 (11.22) 14 (23.73) 0.002b 0.12 (0.01, 1.10) 4.74 (1.48, 15.17)b
Small for gestational age 3 (5.88) 2 (2.04) 2 (3.39) 0.417a 3.55 (0.43, 29.01) 2.05 (0.19, 22.13)
Large for gestational age 3 (5.88) 15 (15.31) 18 (30.51) 0.002b 0.25 (0.06, 1.00) 4.30 (1.61, 11.48)b
Neonatal hypoglycemia 6 (11.76) 16 (16.33) 10 (16.95) 0.708 0.71 (0.25, 2.07) 0.74 (0.28, 1.96)
Neonatal jaundice 5 (7.10) 7 (7.10) 9 (15.30) 0.262 1.33 (0.36, 5.02) 2.35 (0.73, 7.57)
NRDS 6 (3.06) 3 (3.06) 7 (11.86) 0.040ab 1.86 (0.31, 11.17) 7.18 (1.24, 41.61)b
NICU admission 11 (21.57) 18 (18.37) 16 (21.57) 0.435 0.62 (0.21, 1.86) 1.66 (0.69, 4.00)
Overweight Cesarean delivery 33 (53.23) 74 (57.81) 51 (53.23) 0.031b 0.80 (0.42, 1.54) 1.55 (0.77, 3.10)
Assisted vaginal delivery 3 (4.84) 10 (7.81) 4 (5.80) 0.804a 0.50 (0.12, 2.14) 0.74 (0.20, 2.78)
Vaginal delivery 26 (41.94) 44 (34.38) 14 (20.29) 0.025b 1.47 (0.76, 2.85) 0.68 (0.32, 1.43)
Gestational hypertension 3 (4.84) 14 (10.94) 13 (18.84) 0.042b 0.32 (0.09, 1.22) 2.73 (1.07, 6.98)b
Preeclampsia 8 (12.9) 14 (10.94) 10 (14.49) 0.761 1.13 (0.42, 3.06) 1.20 (0.46, 3.14)
PROM 17 (27.42) 35 (27.34) 13 (18.84) 0.376 0.90 (0.45, 1.82) 0.55 (0.25, 1.19)
Preterm birth 10 (16.13) 15 (11.72) 8 (11.59) 0.656 / /
Postpartum hemorrhage 6 (9.68) 27 (21.09) 11 (15.94) 0.140 0.41 (0.16, 1.09) 0.51 (0.22, 1.22)
Macrosomia 10 (16.13) 18 (14.06) 16 (23.19) 0.261 1.09 (0.44, 2.72) 2.48 (1.03, 5.96)b
Small for gestational age 3 (4.84) 4 (3.13) 0 0.214 1.98 (0.37, 10.68) /
Large for gestational age 11 (17.74) 22 (17.19) 20 (28.99) 0.122 0.98 (0.41, 2.30) 2.38 (1.06, 5.36)b
Neonatal hypoglycemia 7 (11.29) 20 (15.63) 11 (15.94) 0.688 0.70 (0.27, 1.82) 0.81 (0.33, 1.97)
Neonatal jaundice 10 (16.13) 19 (14.84) 13 (18.84) 0.768 1.10 (0.46, 2.63) 1.21 (0.52, 2.83)
NRDS 7 (11.29) 11 (8.59) 7 (10.14) 0.829 0.97 (0.29, 3.33) 0.736 (0.21, 2.62)
NICU admission 23 (37.10) 39 (30.47) 22 (31.88) 0.654 1.12 (0.55, 2.28) 0.88 (0.42, 1.86)
Obese Cesarean delivery 23 (65.71) 76 (62.81) 49 (85.96) 0.006b 1.06 (0.45, 2.46) 3.31 (1.40, 7.84)b
Assisted vaginal delivery 2 (5.71) 6 (4.96) 1 (1.75) 0.640a 1.98 (0.30, 13.17) 0.45 (0.05, 4.16)
Vaginal delivery 10 (28.57) 39 (32.23) 7 (12.28) 0.018b 0.85 (0.36, 2.03) 0.33 (0.14, 0.82)b
Gestational hypertension 3 (8.57) 11 (9.09) 6 (10.53) 0.939 0.99 (0.24, 4.05) 1.41 (0.47, 4.29)
Preeclampsia 2 (5.71) 14 (11.57) 14 (24.56) 0.020b 0.50 (0.10, 2.56) 4.12 (1.58, 10.75)b
PROM 7 (20.00) 26 (21.49) 12 (21.05) 0.982 1.12 (0.42, 2.95) 0.94 (0.42, 2.09)
Preterm birth 7 (20.00) 19 (15.70) 8 (14.04) 0.745 / /
Postpartum hemorrhage 5 (14.29) 18 (14.88) 9 (15.79) 0.979 0.78 (0.26, 2.39) 1.10 (0.45, 2.71)
Macrosomia 3 (8.57) 19 (15.70) 19 (33.33) 0.004b 0.47 (0.12, 1.80) 3.30 (1.45, 7.55)b
Small for gestational age 2 (5.71) 2 (1.65) 2 (3.51) 0.251a 3.71 (0.44, 31.08) 2.23 (0.27, 18.45)
Large for gestational age 3 (8.57) 26 (21.49) 25 (43.86) <0.001b 0.32 (0.09, 1.17) 3.27 (1.55, 6.89)b
Neonatal hypoglycemia 8 (22.86) 19 (15.70) 10 (17.54) 0.616 1.83 (0.69, 4.86) 0.97 (0.40, 2.33)
Neonatal jaundice 3 (8.57) 18 (14.88) 2 (3.51) 0.067 0.54 (0.14, 2.07) 0.22 (0.05, 1.02)
NRDS 5 (14.29) 8 (6.61) 6 (10.53) 0.330 3.66 (0.88, 15.27) 2.57 (0.65, 10.19)
NICU admission 12 (34.29) 32 (26.45) 20 (35.09) 0.420 1.70 (0.67, 4.30) 1.37 (0.64, 2.92)

Values are expressed as number (percentage). GWG, gestational weight gain; BMI, body mass index; aOR, adjusted odds ratio; CI, confidence interval; PROM, premature rupture of membranes; NRDS, neonatal respiratory distress syndrome; NICU, neonatal intensive care unit; aFisher exact test; bSignificant associations.