FIGURE 2.

FRAIL1 is skeletal muscle‐enriched and associated with characteristics of aging muscle. (a) GTEx bulk tissue expression levels of FRAIL1 lncRNA expressed as the median TPM value for each human tissue type relative to the expression level in skeletal muscle. (b) Overview of human study participant characteristics and phenotypic measurements. (c) Relative skeletal muscle FRAIL1 lncRNA level across study participants. Data are organized by age group and sex and normalized to the average FRAIL1 lncRNA level in young males. p Values were determined by one‐way ANOVA. (d–f) Age‐ and sex‐specific muscle function outcomes and muscle mass estimates maximal knee extension muscle strength (d), peak knee extension power (e), leg lean mass (f), and skeletal muscle index (g) in young males (YM), young females (YF), older males (OM), and older females (OF). *p < 0.05, ****p < 0.0001.