FIGURE 3.

The transcription factors RBPJ, TEAD3, MYOG, and FOXO3 potentially regulate FRAIL1 expression. (a) The JASPAR database was queried for transcription factor binding sites located within the promoter region 350 nucleotides upstream of the FRAIL1 transcription start site. (b) Human vastus lateralis abundance levels of mRNAs encoding the transcription regulators RBPJ, TEAD3, MYOG, and FOXO3. Data are organized by age group and sex. For a comprehensive list of identified transcription factor binding sites and expression levels, see Figure S3. Horizontal bars indicate mean values from each group, false discovery rate (FDR) was determined by Benjamini‐Hochberg correction, and p values were determined by one‐way ANOVA. *p < 0.05, **p < 0.001.