Table 1.
Marginal and conditional association test results for the lead IKZF1 SNPs at three independent childhood ALL association signals in Hispanic/Latino individuals in the California Cancer Records Linkage Project
| IKZF1 SNP rsID (GWAS signal) | Chromosome 7 location (bp, hg38) | Risk allele | RAF |
Marginal test |
Conditional test 1a |
Conditional test 2b |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall | Cases | Controls | OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | |||
| rs4917017 (signal 1) | 50295636 | A | 0.437 | 0.569 | 0.407 | 1.41 (1.33–1.49) | 2.05 × 10−17 | – | – | – | – |
| rs10272724 (signal 2) | 50409515 | C | 0.268 | 0.300 | 0.260 | 1.30 (1.22–1.39) | 7.49 × 10−10 | 1.29 (1.20–1.37) | 4.39 × 10−9 | – | – |
| rs76880433 (signal 3) | 50384350 | T | 0.153 | 0.267 | 0.127 | 1.37 (1.27–1.46) | 1.62 × 10−10 | 1.22 (1.12–1.32) | 8.43 × 10−5 | 1.44 (1.33–1.55) | 4.67 × 10−11 |
RAF, risk allele frequency; CI, confidence interval.
a
In conditional test 1, the association tests were repeated adjusting for the genotype of SNP rs4917017 (lead SNP in signal 1).
b
In conditional test 2, the association tests were repeated adjusting for the genotype of both SNP rs4917017 (lead SNP in signal 1) and SNP rs10272724 (lead SNP in signal 2).