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Symbols indicate geometric means and whiskers indicated 95% CIs. T0 indicates preactivation period, 1 to 21 days before randomization day; T1, 0 to 20 days post randomization and activation (immediate activation group), or 0 to 20 days after randomization date (delayed group); T2, 21 to 41 days post activation (immediate group), or 0 to 20 days post activation (delayed group).
