| (i) Estimation Program Interface (EPI) Suite Data program (EPI
Suite) |
provides quantitative structure–property
relationship
(QSPR) models to predict a variety of key chemical properties, fate
and transport parameters, and acute and chronic toxicity thresholds
to aquatic organisms based on chemical structure |
(49) |
| (ii) Toxicity Forecaster (ToxCast) |
compiles high-throughput in vitro toxicity
data targeting lower levels of biological organization that are often
subsequently linked to apical end points via adverse outcome pathways
(AOPs); newly developed chemicals can be screened in ToxCast based
on structural data |
(50) |
| (iii) Sequence Alignment
to Predict Across Species Susceptibility
(SeqAPASS) |
uses protein sequence alignment information
to evaluate sequence
similarity among a wide array of species and to estimate susceptibility
of nontarget species |
(51) |
