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. 2024 Apr 16;14(17):12147–12157. doi: 10.1039/d4ra01483a

α-Glucosidase and α-amylase inhibitory effects of 1–13.

Compounds Inhibition (IC50, μM)
α-Glucosidase α-Amylase
1 31.3 ± 2.2 52.1 ± 2.3
2 37.7 ± 1.7 45.3 ± 1.9
3 33.1 ± 1.5 56.4 ± 2.0
4 33.8 ± 1.6 36.5 ± 1.8
5 105.1 ± 2.8 >200
6 99.6 ± 3.4 135.2 ± 3.3
7 148.1 ± 2.5 >200
8 40.5 ± 1.9 44.5 ± 2.3
9 42.4 ± 2.5 39.8 ± 2.5
10 107.7 ± 2.9 >200
11 136.5 ± 3.7 148.6 ± 4.2
12 >200 127.4 ± 3.1
13 >200 166.5 ± 3.7
Acarbose a 47.1 ± 1.4 145.7 ± 2.2
a

Acarbose was used as a positive control.