α-Glucosidase and α-amylase inhibitory effects of 1–13.
Compounds | Inhibition (IC50, μM) | |
---|---|---|
α-Glucosidase | α-Amylase | |
1 | 31.3 ± 2.2 | 52.1 ± 2.3 |
2 | 37.7 ± 1.7 | 45.3 ± 1.9 |
3 | 33.1 ± 1.5 | 56.4 ± 2.0 |
4 | 33.8 ± 1.6 | 36.5 ± 1.8 |
5 | 105.1 ± 2.8 | >200 |
6 | 99.6 ± 3.4 | 135.2 ± 3.3 |
7 | 148.1 ± 2.5 | >200 |
8 | 40.5 ± 1.9 | 44.5 ± 2.3 |
9 | 42.4 ± 2.5 | 39.8 ± 2.5 |
10 | 107.7 ± 2.9 | >200 |
11 | 136.5 ± 3.7 | 148.6 ± 4.2 |
12 | >200 | 127.4 ± 3.1 |
13 | >200 | 166.5 ± 3.7 |
Acarbose a | 47.1 ± 1.4 | 145.7 ± 2.2 |
Acarbose was used as a positive control.