Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 May;30(5):500–511. doi: 10.1261/rna.079953.124

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2024 Jarmoskaite and Li; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article, published in RNA, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

FIGURE 4. — ADAR1 promotes tumor growth by suppressing dsRNA sensing. (Left) Increased ADAR1 expression in tumors (red arrow) leads to efficient editing of endogenous dsRNAs, including abnormal dsRNAs that may accumulate in cancer cells. Through editing dependent and independent mechanisms, ADAR1 inhibits spontaneous activation of MDA5 and PKR, thus promoting tumor growth and preventing immune recognition, even in the presence of checkpoint inhibitors. (Right) ADAR1 deletion unleashes the innate immune response against cellular dsRNAs in cancer cells, leading to inflammation and enhanced sensitivity to checkpoint inhibitors (via the MDA5 pathway) and triggering apoptosis (via the PKR pathway).