TABLE 3.
Hepatology subgroup, week 4 kPa <7 versus ≥7
| Liver kPA <7 | Liver kPA ≥7 | ||||
|---|---|---|---|---|---|
| N | Mean (SD) Median (IQR) N (%) |
N | Mean (SD) Median (IQR) N (%) |
p | |
| Year of treatment a | 60 | 2020.0 (1.14) | 16 | 2019.8 (1.11) | 0.59 |
| Before April 2020 b | 60 | 33 (55) | 16 | 9 (56) | 0.93 |
| Sex, male b | 60 | 38 (63) | 16 | 13 (81) | 0.18 |
| Race, White b | 60 | 30 (50) | 16 | 9 (56) | 0.66 |
| Age a | 60 | 46.6 (12.0) | 16 | 47.2 (8.4) | 0.86 |
| Frequencies of alcohol consumption | |||||
| Age at first drink c | 60 | 15.3 (4.2) 16 (14–17) |
16 | 11.4 (4.7) 13 (8–15) |
0.0018 0.0054 |
| Average drink per day c | 60 | 14.3 (6.7) 12.9 (9.0–17.1) |
16 | 18.7 (7.5) 17.1 (15.0–24.1)3 |
0.024 0.022 |
| Drinks per 30 d c | 60 | 335 (230) 314 (157–472) |
16 | 477 (272) 449 (383–708) |
0.039 0.044 |
| Heavy-drinking days in last 90 d c | 60 | 66.0 (26.2) 78 (43–90) |
16 | 68.3 (30.6) 86 (59–90) |
0.76 0.69 |
| Heavy-drinking years c | 59 | 15.2 (10.6) 12.7 (8.0–20.5) |
16 | 20.9 (9.7) 21.9 (12.6–28.5) |
0.056 0.045 |
| Number of drinking days in last 90 d c | 60 | 66.4 (24.7) 80.5 (48–90) |
16 | 70.4 (27.0) 86 (59–90) |
0.78 0.64 |
| Total lifetime number of drinks (thousands) c | 59 | 63.9 (60.2) 43.7 (26.1–80.2) |
16 | 98.9 (51.9) 87.2 (62.2–131.3) |
0.037 0.0065 |
| Total lifetime drink c (kg) | 59 | 895 (842) 612 (366–1122) |
16 | 1385 (726) 1221 (870–1838) |
0.037 0.0065 |
| Day 1 lab values | |||||
| Total bilirubin a | 60 | 0.58 (0.32) 0.50 (0.35–0.70 |
16 | 1.13 (2.0) 0.65 (0.35–0.95) |
0.29 0.34 |
| GGT c | 60 | 126 (151) 66 (33–145) |
16 | 430 (698) 181 (92–415) |
0.10 0.0026 |
| MCV a | 60 | 93.7 (5.71) 93.8 (91.3–97.0) |
16 | 95.9 (6.96) 95.7 (91.7–97.7) |
0.20 0.33 |
| Platelet count a | 59 | 229 (81.7) 227 (169–294) |
16 | 185 (87.2) 152 (135–249) |
0.060 0.044 |
| ALT c | 60 | 45.4 (38.9) 34 (24–59) |
16 | 55.1 (27.7) 53 (31–83) |
0.36 0.080 |
| AST c | 60 | 55.1 (42.4) 38 (22–77) |
44 | 102.9 (75.4) 87 (45–142) |
0.026 0.011 |
| Day 21 lab values | |||||
| Total bilirubin a | 59 | 0.37 (0.17) 0.30 (0.20–0.50) |
16 | 0.82 (1.74) 0.30 (0.25–0.5) |
0.32 0.81 |
| GGT c | 59 | 60.1 (61.3) 43 (26–68) |
16 | 140.7 (158.2) 76 (63–135) |
0.063 0.0009 |
| MCV a | 52 | 93.4 (5.53) 93.2 (89.6–97.6) |
16 | 96.2 (5.71) 95.5 (92.8–98.7) |
0.086 0.16 |
| Platelet count a | 52 | 274 (74.3) 271 (219–316) |
16 | 223 (87.4) 220 (156–278) |
0.034 0.057 |
| ALT c | 59 | 26.0 (12.3) 23 (18–30) |
16 | 39.6 (21) 29 (24–55) |
0.025 0.014 |
| AST c | 59 | 23.2 (7.9) 21 (17–27) |
16 | 38.2 (24.0) 29 (26–37) |
0.026 0.0006 |
| Baseline AUDIT | |||||
| Question 1 d | 60 | 3.80 (0.58) 4 (4–4) |
16 | 3.81 (0.75) 4 (4–4) |
0.94 0.48 |
| Question 2 d | 60 | 3.40 (0.94) 4 (3–4) |
16 | 3.25 (1.13) 4 (2.5–4) |
0.59 0.71 |
| Question 3 d | 60 | 3.55 (0.72) 4 (3–4) |
16 | 3.50 (1.10) 4 (3.5–4) |
0.86 0.63 |
| Question 4 d | 60 | 3.18 (1.21) 4 (3–4) |
16 | 3.00 (1.37) 3.5 (2.5–4) |
0.64 0.57 |
| Question 5 d | 60 | 2.08 (1.25) 2 (1–3) |
16 | 1.94 (1.29) 2 (1–3) |
0.68 0.66 |
| Question 6 d | 60 | 2.35 (1.55) 3 (1–4) |
16 | 2.63 (1.75) 3.5 (0.5–4) |
0.54 0.43 |
| Question 7 d | 60 | 2.52 (1.31) 3 (1–4) |
16 | 2.75 (1.48) 3 (1.5–4) |
0.54 0.37 |
| Question 8 d | 60 | 1.87 (1.24) 2 (1–3) |
16 | 1.50 (1.37) 1 (0–3) |
0.31 0.29 |
| Question 9 d | 60 | 1.23 (1.69) 0 (0–2) |
16 | 0.88 (1.63) 0 (0–1) |
0.45 0.37 |
| Question 10 d | 60 | 3.57 (1.17) 4 (4–4) |
16 | 3.50 (1.16) 4 (4–4) |
0.84 0.65 |
| AUDIT-C score c | 60 | 10.8 (1.8) 12 (10–12) |
16 | 10.6 (2.1) 12 (9.5–12) |
0.73 0.98 |
| AUDIT-D score c | 60 | 7.6 (3.1) 8 (6–11) |
16 | 7.6 (3.1) 8.5 (5.5–9.5) |
0.95 0.98 |
| AUDIT-H score c | 60 | 9.2 (3.6) 10 (7–12) |
16 | 8.6 (3.2) 9 (7–11) |
0.57 0.56 |
| AUDIT total score c | 60 | 27.6 (6.8) 28 (22–34) |
16 | 26.8 (5.9) 28 (26.5–29.5) |
0.67 0.57 |
| Other SUD current b | 60 | 18 (30) | 16 | 3 (19) | 0.37 |
| Other SUD lifetime b | 60 | 38 (63) | 16 | 10 (63) | 0.95 |
| Anxiety current b | 60 | 21 (35) | 16 | 4 (25) | 0.45 |
| Anxiety lifetime b | 60 | 31 (52) | 16 | 8 (50) | 0.91 |
| Anxiety, no PTSD or OCD current b | 60 | 12 (20) | 16 | 2 (13) | 0.49 |
| Anxiety, no PTSD or OCD lifetime b | 60 | 14 (23) | 16 | 3 (19) | 0.70 |
| Mood current b | 60 | 17 (23) | 16 | 1 (6) | 0.082 |
| Mood lifetime b | 60 | 26 (43) | 16 | 4 (25) | 0.18 |
| Depression current b | 60 | 15 (25) | 16 | 1 (6) | 0.10 |
| Depression lifetime b | 60 | 25 (42) | 16 | 4 (25) | 0.22 |
| PTSD current b | 60 | 11 (18) | 16 | 3 (19) | 0.97 |
| PTSD lifetime b | 60 | 20 (33) | 16 | 6 (38) | 0.75 |
| Pharmacotherapy for AUD | |||||
| Prescribed at discharge | 60 | 38 (63) | 16 | 6 (38) | 0.063 |
| LSM liver kPA | |||||
| LSM week 1 (kPa) c | 50 | 5.5 (2.9) 5.1 (3.8–6.2) |
14 | 18.9 (22.0) 12.1 (7.0–14.8) |
0.040 <0.0001 |
| LSM week 2 (kPa) c | 55 | 4.8 (2.0) 4.5 (3.6–5.7) |
16 | 17.2 (16.6) 11.4 (7.4–16.8 |
0.0091 <0.0001 |
| LSM week 4 (kPa) | 60 | 4.5 (1.0) 4.6 (3.8–5.2) |
16 | 18.5 (16.6) 12.1 (9.0–20.5) |
NA |
| Week 26 Audit | |||||
| Question 1 d | 60 | 1.37 (1.72) 0 (0–3) |
16 | 1.56 (1.97) 0 (0–4) |
0.66 0.65 |
| Question 1 >0 b | 60 | 26 (43) | 16 | 7 (44) | 0.98 |
| Question 7 >0 b | 60 | 20 (33) | 16 | 6 (38) | 0.75 |
| AUDIT-C ≥3 (F), ≥4 (M) b | 60 | 25 (42) | 16 | 6 (38) | 0.76 |
| Week 52 Audit | |||||
| Question 1 d | 16 | 1.57 (1.77) 1 (0–4) |
7 | 2.14 (1.77) 3 (0–4) |
0.45 0.51 |
| Question 1>0 b | 28 | 15 (54) | 7 | 5 (71) | 0.39 |
| Question 7 >0 b | 28 | 13 (46) | 7 | 5 (71) | 0.24 |
| AUDIT-C ≥3 (F), ≥4 (M) b | 28 | 13 (46) | 7 | 5 (71) | 0.24 |
a
p value is from a t test.
b
p value is from a chi-square test.
c
p values are from a t test and a Wilcoxon rank sum test.
d
p values are from a t test and ordinal logistic regression.
Abbreviations: ALT, alanine aminotransaminase; AST, aspartate aminotransferase; AUD, alcohol use disorder; AUDIT, Alcohol Use Disorder Identification Test; AUDIT-C, Alcohol Use Disorder Identification Test-Consumption; AUDIT-D, Alcohol Use Disorder Identification Test-Dependence; AUDIT-H, Alcohol Use Disorder Identification Test-Harm; GGT, gamma-glutamyl transferase; LSM, liver stiffness measurement; MCV, mean corpuscular volume; OCD, obsessive-compulsive disorder; PTSD, post-traumatic stress disorder; SUD, substance use disorder.