Table 2.
Characterization of exosome contents from lung transplant recipients with BOS or RAS compared to stable recipients (controls without CLAD). Significantly different proteins (p<0.05) in BOS vs RAS after student’s t-test and multiple testing by Benjamini Hochberg correction.
| Exosomal proteins |
Stable (n=5) |
BOS (n=14) Fold change |
RAS (n=13) Fold change |
p values BOS vs RAS |
P-Adj (BH) |
|---|---|---|---|---|---|
| Collagen V | 1 | 2.44 | 3.84 | 0.0537 | 0.0690 |
| Kα1 tubulin | 1 | 1.85 | 1.22 | 0.0201 | 0.0301 |
| HLA-DQ | 1 | 1.43 | 3.35 | 0.0001 | 0.0003 |
| HLA-DR | 1 | 3.98 | 12.05 | 0.0002 | 0.00045 |
| HLA class I | 1 | 10.06 | 11.17 | 0.5127 | 0.5127 |
| NFkB | 1 | 3.33 | 8.08 | 0.0003 | 0.00054 |
| CIITA | 1 | 12.5 | 25.8 | 0.1434 | 0.16132 |
| PIGR | 1 | 0.93 | 2.22 | 0.0001 | 0.0003 |
| 20S proteasome | 1 | 0.47 | 1.19 | 0.0001 | 0.0003 |
All values are normalized to CD9 blots. Fold change values are compared to stable (controls without CLAD). p values and p-Adj values are represented after multiple correction test between BOS and RAS LTxR groups.
BOS, bronchiolitis obliterans syndrome; CLAD, chronic lung allograft dysfunction; RAS, restrictive allograft syndrome.