STRADα knockdown by siRNA significantly upregulated fibrosis markers (FN and Col-I) in BEAS-2B cells. (A) Western blot analysis of STRADα, FN, and Col-I expression in BEAS-2B cells after STRADα knockdown by siRNA (STRADα siRNA) or knockdown with control (ConsiRNA). (B, C) Densitometry analysis showed knockdown of STRADα significantly upregulated FN (n=3, p=0.001) and Col-I (n=3, p=0.008). Values are mean ± SD of three independent experiments.