Figure 1.

Combinatorial anatomical connectivity. (A) Computational analysis of cortical pathways suggests that a subgroup of regions works as a “rich club” (orange circles in the middle): a set of highly interconnected nodes that play a major role in determining the flow of signals across the brain. (B) The neuroarchitecture also includes multiple large-scale connectional systems, such as via the BG, as illustrated here. Additional systems include those involving the thalamus, the hypothalamus, the BLA, and the cerebellum, among others.