Table 2.
Copeptin performance and predictability.
| Copeptin performance | ||||||
|---|---|---|---|---|---|---|
| Author | Copeptin assay | Clinical sample | Sampling point | Sample storage | Detection limit | Variability |
| Ameen et al. 28 | ELISA | Venous blood, EDTA | <24 h of admission | −20°C | NR | NR |
| Assaad et al. 29 | ELISA | Blood | <48 h of admission | −20°C | NR | NR |
| Battista et al. 30 | TRACE | Plasma | Up to 72 h of admission | −70°C | 0.9 pmol/l | Inter-assay variation <12% |
| Jiang et al. 31 | ELISA | Venous blood | Up to 72 h of admission | −4°C | NR | NR |
| Jochberger et al. 21 | CLIA | EDTA plasma | 24 h of admission | −80°C | 1.7 pmol/l | Inter-assay variation <20% |
| Koch et al. 32 | Fluorescent immunoassay | EDTA Plasma | At admission | −80°C | NR | NR |
| Kloter et al. 33 | CLIA | Blood | NR | −20°C | 0.4 pmol/l | NR |
| Lee et al. 26 | ELISA | Arterial/ venous blood | <24 h of admission | −20°C | 0.24 pmol/l | Inter-assay variation <15% |
| Lesur et al. 34 | ELISA | Blood | NR | NR | Upper limit 248 pmol/l | NR |
| Morgenthaler et al. 35 | CLIA | Arterial/ venous blood | On admission | −70°C | 1.7 pmol/l | Inter-assay variation <20% |
| Palmiere et al. 36 | ELISA | Venous blood | Prior to autopsy | −70°C | 3.9 pmol/l | Inter-assay variation <20% |
| Schlapbach et al. 27 | Fluorescent immunoassay | Umbilical blood | As soon as birth | −80°C | 4.8 pmol/l | NR |
| Sobhy et al. 37 | ELISA | Serum | On admission | −80°C | NR | NR |
| Struck et al. 38 | HPLC | Serum/plasma | NR | −20°C | NR | NR |
| Zhang et al. 39 | NR | |||||
| Copeptin predictability | ||||||
| Author | Outcome | Cut-off | AUC | AUC 95% CI | Sensitivity | Specificity |
| Ameen et al. 28 | Mortality within 28th day | NR | 0.845 | 0.724–0.966 | NR | NR |
| Assaad et al. 29 | Mortality within 10th day | >11 pmol/l | 0.660 | NR | 57.89% | 76.19% |
| Battista et al. 30 | Mortality within 30th day | 23.2 pmol/l | 0.845 | NR | 74% | 87% |
| Jiang et al. 31 | Mortality within 28th day | NR | 0.951 | NR | NR | NR |
| Jochberger et al. 21 | NR | |||||
| Koch et al. 32 | NR | |||||
| Kloter et al. 33 | Mortality within 30th day | 0.820 | 0.76-0.89 | NR | NR | |
| Lee et al. 26 | NR | |||||
| Lesur et al. 34 | NR | |||||
| Morgenthaler et al. 35 | Not defined | 96 pmol/l | 0.750 | 0.610–0.860 | 61.5% | 83.8% |
| Palmiere et al. 36 | NR | |||||
| Schlapbach et al. 27 | NR | |||||
| Sobhy et al. 37 | Mortality | 58.1 pmol/l | 0.880 | NR | 96.6% | 61.3% |
| Struck et al. 38 | NR | |||||
| Zhang et al. 39 | Mortality within 28th day | 21.5 pmol/l | 0.826 | 0.780–0.871 | 85.3% | 59.8% |