Table 2.
Radiological response in the FAS and pathological response in the surgery set.
| Best responses | |
|---|---|
| Radiological evaluation, n (%) | Patients (n=32) |
| CR | 4 (12.5) |
| PR | 23 (71.9) |
| SD | 4 (12.5) |
| PD | 1 (3.1) |
| ORR | 27 (84.4, 68.3–93.1%) |
| DCR | 31 (96.9, 84.3–99.5%) |
| Pathological evaluation, n (%) | Patients (n=29) |
| Pathology T-stage | |
| ypT0 | 5 (17.2) |
| ypT1 | 5 (17.2) |
| ypT2 | 4 (13.8) |
| ypT3 | 10 (34.5) |
| ypT4 | 3 (10.3) |
| ypTx | 2 (6.9) |
| Downing T | 23 (79.3) |
| Pathology N-stage | |
| ypN0 | 16 (55.2) |
| ypN1 | 7 (24.1) |
| ypN2 | 4 (13.8) |
| ypN3 | 2 (6.9) |
| Downing N | 21 (72.4) |
| Nerve invasion | |
| 0 | 17 (58.6) |
| 1 | 8 (27.6) |
| Unknown | 4 (13.8) |
| Vessel invasion | |
| 0 | 14 (48.3) |
| 1 | 11 (37.9) |
| Unknown | 4 (13.8) |
| Pathological regression (as per the Mandard criteria) | |
| TRG0 (pCR rate) | 5 (17.2) |
| TRG1 | 11 (37.9) |
| TRG2 | 10 (34.5) |
| TRG3 | 3 (10.3) |
| MPR rate | 16 (55.2) |
| TNM stage after operation | |
| ypT0N0 | 5 (17.2) |
| Stage I | 8 (27.6) |
| Stage II | 11 (37.9) |
| Stage III | 5 (17.2) |
Data are presented as n (%) or n (%, 95% CI).
CR, complete response; DCR, disease control rate; FAS, full analysis set; MPR, major pathological response; ORR, overall response rate; pCR, pathological complete response; PD, progressive disease; PR, partial response; SD, stable disease; TNM, tumour/node/metastases; TRG, tumour regression grading.