Table 3.

Female representation and outcomes in recent RCTs on management of out-of-hospital cardiac arrest

Study name	Year	Intervention	Indication	n	Women (%)	Main outcomes in relation to sex
COACT86	2019	Immediate vs. delayed angiography	OHCA without ST-segment elevation	552	20%	Similar results in women and men (no benefit of immediate angiography on survival at 90 days)
TOMAHAWK81	2021	Immediate vs. delayed angiography	OHCA without ST-segment elevation	554	30%	Immediate angiography no benefit over delayed with respect to 30-day mortality—no interaction with sex
BOX trial82	2022	Oxygen targets	OHCA	789	19%	Similar results in women and men
BOX trial83	2022	Blood pressure targets	OHCA	789	19%	Similar results in women and men
INCEPTION84	2023	Extracorporeal vs. conventional CPR	Refractory OHCA	134	10%	No subgroup analysis on sex
ARREST87	2023	Immediate transfer to CAC vs. standard care	OHCA without ST-segment elevation	827	32%	Similar results in women and men (no reduction in 30-day mortality)
TAME88	2023	Mild hypercapnia vs. normocapnia		1700	23%	Similar result in women and men (no effect of hypercapnia on 6 months mortality)

BOX, Blood Pressure and OXygenation Targets After OHCA; CAC, cardiac arrest centre; COACT, Coronary Angiography After Cardiac Arrest; INCEPTION, Early Initiation of Extracorporeal Life Support in Refractory OHCA; OHCA, out-of-hospital cardiac arrest; RCT, randomized controlled trial; TAME, Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest; TOMAHAWK, Immediate Unselected Coronary Angiography Versus Delayed Triage in Survivors of Out-of-hospital Cardiac Arrest Without ST-segment Elevation.