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. 2024 Apr 16;19(4):e0301367. doi: 10.1371/journal.pone.0301367

Fig 4. Relationship between anti-SARS-CoV-2 Spike IgG and percent spike inhibition in nursing home residents—Georgia, December 2020–July 2022, n = 37.

Fig 4

Pearson’s correlation coefficient® was used to evaluate the relationship between anti-S IgG titers and percent spike inhibition. A SARS-CoV-2 infected participant was defined as a participant with infection documented in the electronic health record or confirmed by laboratory testing using real-time reverse-transcriptase polymerase chain reaction (rRT-PCR), point of care BinaxNOW™ COVID-19 Ag Card antigen test (BinaxNOW), or seroconversion as indicated by the presence of anti-nucleocapsid antibody (anti-N) IgG titer to SARS-CoV-2 above the cut-off for seropositivity using Meso Scale Discovery (MSD) immunoassay (MSD; Rockville, MD, USA). Vaccine-only immunity was defined as the immune protection in infection-naïve individuals who have had one or more doses of an mRNA COVID-19 vaccine and remained infection-naïve after vaccination initiation. Hybrid immunity was defined as the immune protection in individuals who have had one or more doses of an mRNA COVID-19 vaccine and have evidence of at least one SARS-CoV-2 infection before or after vaccination initiation.