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. 2024 Apr 16;19(4):e0301367. doi: 10.1371/journal.pone.0301367

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Fig 7 — A: Relationship between anti-SARS-Cov-2 Spike IgG and Memory B cell S IgG in nursing home residents—Georgia, December 2020–July 2022; n = 15. Pearson’s correlation coefficient (R) was used to evaluate the relationship between anti-S IgG titers and percent spike inhibition (virus neutralizing capacity). Hybrid immunity R = 0.56, p = 0.0042. Vaccine-induced immunity: R = 0.47, p = 0.35. Footnote: Vaccine-only immunity was defined as the immune protection in infection-naïve individuals who have had one or more doses of an mRNA COVID-19 vaccine and remained infection-naïve after vaccination initiation. Hybrid immunity was defined as the immune protection in individuals who have had one or more doses of an mRNA COVID-19 vaccine and have evidence of at least one SARS-CoV-2 infection before or after vaccination initiation. B: Relationship between full-length Spike IgG Memory B Cells (MBC) and Percent Spike Inhibition in nursing home residents—Georgia, December 2020–July 2022; n = 15. Pearson’s correlation coefficient (R) was used to evaluate the relationship between full-length Spike IgG Memory B Cells (MBC) and Percent Spike Inhibition. Hybrid immunity R = 0.33, p = 0.11. Vaccine-induced immunity: R = 0.47, p = 0.35. Footnote: Vaccine-only immunity was defined as the immune protection in infection-naïve individuals who have had one or more doses of an mRNA COVID-19 vaccine and remained infection-naïve after vaccination initiation. Hybrid immunity was defined as the immune protection in individuals who have had one or more doses of an mRNA COVID-19 vaccine and have evidence of at least one SARS-CoV-2 infection before or after vaccination initiation.