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. 2023 Nov 5;46(1):2300145. doi: 10.1002/bies.202300145

FIGURE 1.

FIGURE 1

(A) eIF4E influences the major mRNA processing steps, RNA export and translation making it a master regulator of proteome generation. The major steps are shown with a focus on splicing. Note that capping and CPA can also occur post‐transcriptionally but are not shown for simplicity. Red stars indicate steps where eIF4E acts. In all cases, eIF4E interacts with the shown machinery and in some cases eIF4E also influences production of the components of said machines. Note that whether eIF4E influences co‐ or post‐transcriptional processing is unknown; here, we postulate its involved in both. Green barrel indicates the nuclear pore complex, blue is the nucleus and light green the cytoplasm. This figure was generated in Biorender. (B) Summary of factors that bind to and are regulated by eIF4E at each processing step. IPs indicate endogenous immunoprecipitation; direct indicates purified eIF4E and purified factor of interest directly binding; CERT, cytosine enriched regulator of translation identified in [ 29 ]; UTR, untranslated region; USER code, untranslated sequence for regulation. See text for details.