Table 3.
Identification of CNVs and aneuploidies in different ultrasound abnormal manifestation groups.
| Group | Numerical abnormalities of chromosomes | P/LP CNVs | VUS CNVs | Normal | Total | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Total | Trisomy-21 | Trisomy-18 | Trisomy-13 | Monosomy-X | Other | |||||
| A | 2 (0.8) | 0 (0.0) | 1 (0.4) | 0 (0.0) | 0 (0.0) | 1 (0.4) | 3 (1.1) | 20 (7.6) | 237 (90.5) | 262 |
| B | 136 (9.3) | 72 (4.9) | 15 (1.0) | 7 (0.5) | 23 (1.6) | 19 (1.3) | 70 (4.8) | 94 (6.4) | 1,170 (79.6) | 1,470 |
| C | 74 (23.7) | 42 (13.5) | 17 (5.4) | 1 (0.3) | 6 (1.9) | 8 (2.6) | 21 (6.7) | 21 (6.7) | 196 (62.8) | 312 |
| D | 99 (43.4) | 8 (3.5) | 29 (12.7) | 13 (5.7) | 45 (19.7) | 4 (1.8) | 20 (8.8) | 10 (4.4) | 99 (43.4) | 228 |
| Total | 311 (13.7) | 122 (5.4) | 62 (2.7) | 21 (0.9) | 74 (3.3) | 32 (1.4) | 114 (5.0) | 145 (6.4) | 1702 (74.9) | 2,272 |
| χ2 trend | 248.24 | 13.61 | 99.35 | – | 146.06 | – | 16.24 | 1.55 | 191.96 | |
| p-value | <0.0001 | <0.0001 | <0.0001 | – | <0.0001 | – | <0.0001 | >0.05 | <0.0001 | |