Table 1.
Laboratory and clinical parameters throughout the clinical course.
| Parameter | Reference range | Unit | Day 1* | Day 2 | Day 3* | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | Day 9 | Day 10 | Day 11 | Day 12 | Day 13 | Day 14 | Day 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Leucocytes | 4.40–11.6 | [103/μl] | 14.73 | 12.95 | 14.95 | 16.06 | 11.23 | 8.66 | 8.02 | 7.61 | 7.78 | 14.14 | / | 11.4 | 8.07 | 8.64 | 6.18 |
| Platelets | 178–420 | [103/μl] | 285 | 107 | 72 | 67 | 76 | 90 | 100 | 134 | 168 | 190 | / | 195 | 224 | 233 | 239 |
| Creatinine | 14–68 | [μmol/l] | 110 | 88 | 79 | 55 | 51 | 44 | / | / | / | / | / | / | / | 54 | |
| AST | 0–50 | [U/l] | 203 | 191 | 400 | 153 | 63 | / | 57 | / | 27 | / | / | / | / | / | 30 |
| ALT | 0–50 | [U/l] | 97 | 85 | 455 | 339 | 199 | / | 124 | / | 81 | / | / | / | / | / | / |
| Bilirubin total | 5–21 | [mg/dl] | 5.4 | 35.7 | 14.2 | 17.4 | 15.4 | / | 15.7 | / | 14.3 | / | / | / | / | / | / |
| Bilirubin direct | 0–3 | [mg/dl] | / | 25.9 | 8.5 | 9.6 | 7.2 | / | 5.6 | / | 5.1 | / | / | / | / | / | / |
| CRP | 0–5 | [mg/l] | 0.7 | 16.9 | 125.4 | 83.0 | 43.4 | 26.9 | 20.1 | / | 9.6 | / | / | 5.2 | / | / | / |
| Procalcitonin | <0.5 | [ng/ml] | 0.020 | / | 17.48 | 7.25 | 0.810 | / | / | / | / | 0.24 | / | / | / | ||
| Norepinephrine | [μg/kg/min] | 0.8 | 0.25 | 0.2 | 0.05 | / | / | / | / | / | / | / | / | / | / | / | |
| Lactate | 0–2 | [mmol/l] | 19 | 3.33 | 1.64 | 1.47 | 1.46 | 0.92 | 0.76 | 0.78 | 0.76 | 0.95 | / | / | / | / | / |
| Temperature | [°C] | 37.5 | 36.1 | 36.4 | 37.6 | 38 | 37.7 | 37.4 | 37.1 | 36.6 | 36.6 | 36.7 | 36.6 | 36.7 | 36.7 | 36.6 | |
| Interleukin-6 | 0–4.4 | [pg/ml] | 10249 | 764 | / | 14.1 | 7.35 | 8.37 | 8.90 | / | / | / | / | / | / | / | / |
| pH | 7.35–7.45 | 6.9 | 7.26 | 7.39 | 7.37 | 7.49 | 7.47 | 7.40 | 7.38 | 7.39 | 7.41 | / | / | / | / | / | |
| FiO2 | 0.21 | 1.0 | 0.8 | 0.35 | 0.5 | 0.4 | 0.3 | 0.3 | 0.25 | 0.25 | 0.21 | 0.21 | 0.21 | 0.21 | 0.21 | 0.21 | |
| PEEP | 5 | [mmHg] | 26 | 20 | 14 | 8 | 10 | 10 | 8 | / | / | / | / | / | / | / | / |
| P/F ratio | >300 | [mmHg] | 40 | 39 | 30 | 97 | 80 | 81 | 107 | 146 | 97 | 179 | / | / | / | / | / |
| Ventilation mode | PRVC | PRVC | PRVC | PRVC | PRVC | PRVC | HFNC | HFNC | HFNC | HFNC | / | / | / | / | / |
AST – aspartate aminotransferase; ALT – alanine aminotransferase; CRP – C-reactive protein; PEEP – Positive end-expiratory pressure; PRVC – Pressure-regulated volume; HFNC; high flow nasal cannula control. *Indicator of CytoSorb treatment start (1st – 3 h + 2nd – 12 h on Day 1, 3rd – 12 h on Day 3).