Table 1.
Cell proliferation screen of alexidine analogs
| Compound | SRB IC50 (μM) | Fit (R2) | 95% CI | WST IC50 (μM) | Fit (R2) | 95% CI |
|---|---|---|---|---|---|---|
| AX-1 | 10.1 | 0.9461 | 5.9–773.4 | – | – | – |
| AX-2 | N/A | N/A | N/A | N/A | 0.2487 | N/A |
| AX-3 | 2.0 | 0.9835 | 1.8–2.2 | – | – | – |
| AX-4 | 0.8 | 0.9497 | 0.6–0.9 | 3.7 | 0.9553 | 3.2–4.4 |
| AX-5 | 3.4 | 0.8944 | N/A | – | – | – |
| AX-7 | 0.6 | 0.7184 | 0.4–1.5 | 3.0 | 0.9520 | 2.5–3.8 |
| AX-10 | N/A | 0.1939 | 0.01-N/A | – | – | – |
| AD | 1.0 | 0.8977 | 0.7–1.3 | 2.5 | 0.9500 | 2.1–3.0 |
IC50 concentrations, goodness of fit (Fit R2), and 95% confidence intervals (CI) for the SRB and WST-8 proliferation assays in Figure 1 were determined using nonlinear regression. N/A indicates values that were unable to be accurately computed.