Comparison 3. Switch to NVP vs continue on LPV/r.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Virological failure (any VL>50 copie/ml)	1		Hazard Ratio (Fixed, 95% CI)	0.62 [0.41, 0.92]
2 Virological failure (confirmed VL>1000 copies/ml)	1		Hazard Ratio (Fixed, 95% CI)	10.19 [2.36, 43.94]
3 Decline by 10% in CD4% at week 52	1	195	Risk Ratio (M‐H, Fixed, 95% CI)	0.22 [0.07, 0.74]
4 Decline by 1 z‐score in weight‐for‐age at week 52	1	195	Risk Ratio (M‐H, Fixed, 95% CI)	0.32 [0.11, 0.94]
5 ALT increase (Grade 3/4)	1	195	Risk Ratio (M‐H, Fixed, 95% CI)	1.80 [0.55, 5.97]
6 Neutropenia (grade 3/4)	1	195	Risk Ratio (M‐H, Fixed, 95% CI)	1.72 [0.42, 6.99]