Study	Reason for exclusion
Ananworanich 2008	Children younger than 1 year were excluded from the study.
Cotton 2012	The trial did not include an arm that received continuous ART from birth
King 2005	Children included in the study were not treatment naive.
Krogstad 2002	Children included in the study were not treatment naive.
Lockman 2007	No comparison between NNRTI‐based and PI‐based was provided.
Luzuriaga 2004	This trial was not randomised.
NCT00427297	This trial was interrupted for lack of equipoise.
PENPACT1 study team	Children less than 2 years old were poorly represented and no stratification by age was provided for the measure of effect.
Prendergast 2008 (b)	The trial did not include an arm that received continuous ART from birth
Puthanakit 2012	Definition of "early" and "deferred" treatment did not match predefined inclusion criteria.
Wiznia 2000	Children included in the study were not treatment naive.
Wongsawat 2010	Addressing a different comparison: CD4 count versus CD4% as criteria to start treatment