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. 1998 Jul;72(7):5626–5637. doi: 10.1128/jvi.72.7.5626-5637.1998

FIG. 1.

FIG. 1

Concentrations of Rosco and Olo required to inhibit cell cycle progression in HEL and Vero cells. HEL (A, C, and E) and Vero (B and D) cells (3 × 105 to 6 × 105) were seeded in 35-mm dishes (330 to 600 cells/mm2) in the presence or absence of the indicated concentrations of Rosco (A and B), Olo (C and D), or Lova (E). Because of the short duration of some of Olo biological effects, cultures treated with Olo required a medium change at 6 hpi. After 24 h, cells were harvested by trypsinization and resuspended in Telford’s reagent and cellular DNA content was determined by FACS analysis. The percentages of cells in specific phases of the cell cycle are plotted against the drug concentration.