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. 2023 Nov 17;4(2):20210146. doi: 10.1002/EXP.20210146

FIGURE 5.

FIGURE 5

Schematic illustration of adding synthetic N‐series lipids and polymer in NPs for organ‐targeted mRNA delivery. A O‐ and N‐series lipid‐based LNPs with liver and lung targeting ability, respectively. B N‐series lipid 306‐N16B‐based LNP‐mediated preferential transport of mRNA to the lungs. C The preparation process of hLNP with a mixture of 306‐O12B and 306‐N16B lipid. D Percentage of proteins in the protein corona absorbed on lung‐targeting LNP. E Fraction of tumor nodes treated with Tsc2 mRNA‐loaded hLNP and control group. Reproduced with permission.[ 90 ] Copyright 2022, National Academy of Sciences. F The synthetic route of PBAE, a linear end‐capped polymer. G The preparation process of PEG‐coated mRNA NPs containing PBAE polymers. Reproduced with permission.[ 110 ] Copyright 2022, American Association for the Advancement of Science.