Figure 4.

PRONAII Cell Repository of Childhood Leukemia in Mexican Patients: (A) A total of 5,130 samples from patients with Oaxaca, Puebla, and Tlaxcala, in which different components of the bone marrow (blue graph) and peripheral blood (orange graph) were preserved, as well as urine samples (yellow graph). Stored components: RNA, ribonucleic acid; plasma, serum; WBM, whole bone marrow; MSC, mesenchymal stromal cells; MNC, mononuclear cells; BF, buffer-free leukocytes; LB, Leukocytes in Lysis Buffer; FBS, leukocytes stored in fetal bovine serum (FBS). (B) MSCs were obtained from 128 patients. These include patients with ALL and AML, both at diagnosis and at the minimal residual disease (MDR) stage, as well as those with mixed-phenotype acute leukemia (MPAL) and myelodysplastic syndromes (MDS) at diagnosis. Additionally, MSCs from patients with a negative diagnosis of acute leukemia (non-AL) were stored. (C) Different research projects have received 515 specimens from patients.