TABLE 3.

Warnings and precautions for each ASO drug in the FDA-approved drug labeling

ASO Drug	FDA Warnings and Precautions	Shared Warnings and Precautions by Multiple ASO Drugs
Fomivirsen	Ocular inflammation Increased intraocular pressure	Hepatotoxicity Kidney toxicity Hypersensitive reactions
Pegaptanib	Endophthalmitis Increased intraocular pressure
Mipomersen	Black box: Risk of hepatotoxicity Elevation of ALT and AST Hepatic steatosis
Defibrotide	Hemorrhage Hypersensitive reactions
Nusinersen	Thrombocytopenia Coagulation abnormalities Renal toxicity
Inotersen	Black box: Thrombocytopenia Glomerulonephritis and renal toxicity Elevation of ALT and AST Stroke and cervicocephalic arterial dissection Inflammatory and immune effects Hypersensitive reactions Reduced serum vitamin A
Eteplirsen	Hypersensitive reactions
Golodirsen	Renal toxicity Hypersensitive reactions
Viltolarsen	Kidney toxicity
Casimersen	Kidney toxicity