TABLE 1.
Kinetic analysis of multiple-times uptake data of Oatp-mediated statin transport in rat brain
| VBr (pmol/mg) | KIN (pmol/mg·min) |
kout (min−1) |
VBr (pmol/mg) |
KIN (pmol/mg·min) |
kout (min−1) |
VBr (pmol/mg) |
KIN (pmol/mg·min) |
kout (min−1) |
|
|---|---|---|---|---|---|---|---|---|---|
| Control | 82.62 ± 5.55 (95% CI: 71.52, 93.72) |
9.91 ± 0.22 (95% CI: 9.47, 10.35) |
0.12 ± 0.04 (95% CI: 0.04, 0.20) |
69.41 ± 4.50 (95% CI: 60.41, 78.41) |
7.64 ± 0.18 (95% CI: 7.28, 8.00) |
0.11 ± 0.04 (95% CI: 0.03, 0.19) |
75.37 ± 5.12 (95% CI: 65.13, 85.61) |
7.54 ± 0.10 (95% CI: 7.34, 7.74) |
0.10 ± 0.02 (95% CI: 0.06, 0.14) |
| BMP-9 (1.0 μg/kg) | 115.00 ± 6.52** (95% CI: 101.96, 128.04) |
18.40 ± 0.26** (95% CI: 17.88, 18.92) |
0.16 ± 0.04 (95% CI: 0.08, 0.24) |
92.43 ± 7.12** (95% CI: 78.19, 106.67) |
17.56 ± 0.57** (95% CI: 16.42, 18.70) |
0.19 ± 0.08 (95% CI: 0.03, 0.35) |
101.40 ± 2.87** (95% CI: 95.66, 107.14) |
18.25 ± 0.03** (95% CI: 18.19, 18.31) |
0.18 ± 0.03 (95% CI: 0.12, 0.24) |
| BMP-9 (1.0 μg/kg) + LDN193189 (10 mg/kg) | 77.07 ± 9.10 (95% CI: 58.87, 95.27) |
10.79 ± 0.36 (95% CI: 10.07, 11.51) |
0.14 ± 0.04 (95% CI: 0.06, 0.22) |
73.08 ± 4.81 (95% CI: 63.46, 92.32) |
7.31 ± 0.14 (95% CI: 7.03, 7.59) |
0.10 ± 0.03 (95% CI: 0.04, 0.16) |
71.74 ± 5.20 (95% CI: 61.34, 82.14) |
7.89 ± 0.10 (95% CI: 7.69, 8.09) |
0.11 ± 0.02 (95% CI: 0.07, 0.15) |
**p < 0.01 relative to control. VBr, brain volume of distribution; KIN, calculated uptake transfer constant; kout, brain efflux rate coefficient.