TABLE 4.
Prediction of P450-mediated clinical drug interaction potential after oral or inhaled dose of THC or CBDa
| THC | 11-OH-THC | THC-COO-Gluc | CBD | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Oral | Inhaled | Oral | Inhaled | Oral | Inhaled | Oral | Inhaled | |||||
| Enzyme | AUCRhep | AUCRsys | AUCRsys | AUCRhep | AUCRsys | AUCRsys | AUCRhep | AUCRsys | AUCRsys | AUCRhep | AUCRsys | AUCRsys |
| CYP1A2 | 1.25 | 1.02 | 1.08 | NAb | NA | 7.38 | 1.20 | 1.09 | ||||
| CYP3A4 | NA | NA | NA | 9.24 | 1.26 | 1.11 | ||||||
| CYP2B6 | 1.09 | 1.01 | 1.03 | 1.32 | 1.03 | 1.02 | 1.08 | 1.03 | 1.03 | 12.26 | 1.35 | 1.15 |
| CYP2C9 | 1.31 | 1.03 | 1.10 | 1.44 | 1.04 | 1.03 | 1.05 | 1.02 | 1.02 | 9.24 | 1.26 | 1.11 |
| CYP2C19 | 1.40 | 1.03 | 1.13 | NA | NA | 16.32 | 1.48 | 1.21 | ||||
| CYP2D6 | 1.20 | 1.02 | 1.07 | 1.17 | 1.02 | 1.02 | 1.08 | 1.03 | 1.03 | 11.94 | 1.34 | 1.15 |
| CYP2E1 | NA | NA | NA | 37.47 | 2.14 | 1.49 | ||||||
aThe AUCRhep and AUCRsys were calculated for THC, 11-OH-THC and THC-COO-Gluc based on oral or inhaled dosing of THC; the AUCRhep and AUCRsys were calculated for CBD based on oral or inhaled dosing of CBD as described in Materials and Methods.
bNA, not analyzed.