Fig. 2.
Inhibition curves for THC (A) and CBD (B) in time-dependent inhibition study. HLS9 (250 µg/ml) was preincubated with or without cannabinoids for 30 minutes before addition of MPH. The formation rate of metabolite (ritalinic acid) from MPH was expressed as a relative value over the control sample without addition of cannabinoids. Data points represent the mean (±S.D.) of triplicate samples from a single experiment. Lines represent model prediction.