TABLE 4.

Model evaluation for CBD.

			AUC (ng·h/ml)			Cmax (ng/ml)
	Dose (Epidiolex)	N	Mean observed	Mean predicted	PE (%)	Mean observed	Mean predicted	PE (%)
Calibration Datasets
(Taylor et al., 2018)	1500 mg	6	1470a,b	1486a	1.1	260b	214	−17.7
(Taylor et al., 2018)	6000 mg	6	3490a,b	3076a	−11.9	610b	453	−25.7
(Tayo et al., 2020)	200 mg	8	435a,b	648a	49.0	118b	87.0	−26.3
Verification Datasets
(Taylor et al., 2019)	200 mg	8	522a,b	548a	5.0	96.4b	86.2	−10.6
(Crockett et al., 2020)	750 mg	29	1490b	1526	2.4	154b	152	−1.3
(Taylor et al., 2018)	3000 mg	6	2540a,b	2608a	2.7	418b	386	−7.7
(Taylor et al., 2018)	4500 mg	6	3100a,b	2968a	−4.3	677b	441	−34.9
Weighted PE (%)					6.2			−12.3

PK parameters are shown as geometric mean values.

^a AUC_0-last

^b Obtained from a non-compartmental analysis of digitized population-level data due to the discrepancies observed between the reported PK parameters and concentration-time plots.