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. 2020 Mar;48(3):153–158. doi: 10.1124/dmd.119.089334

Fig. 2.

Fig. 2.

(A) Relative mRNA expression of selected proteins involved in the transport and metabolism of gemcitabine in BxPC-3, MIA PaCa-2, and PANC-1. Cytidine deaminase is highlighted (red rectangle). Data are displayed as means of four independent samples studied in triplicate, and error bars are S.D. SLC28A1*: hCNT1, concentrative nucleoside transporter 1; SLC29A1: hENT1, equlibrative nucleoside transporter 1; SLC29A2: CMPK1, uridine/cytosine monophosphate kinase; dCK, deoxycytidine kinase; hENT2, equlibrative nucleoside transporter 2; NME2: CDA, cytidine deaminase; dCTD, deoxycytidine monophosphate deaminase; NdPK, nucleoside diphosphate kinase; NT5C: cdN, cytosolic 5′(3′)-deoxyribonucleotidase; NT5C2: cN-II, cytosolic 5′-nucleotidase II; NT5C3: cN-IIIA, cytosolic 5′-nucleotidase III A; NT5M: CTPS1*, cytidine triphosphate synthase 1; DCTPP1, deoxycytidine triphosphate pyrophosphatase 1; mdN, mitochondrial 5′(3′)-deoxyribonucleotidase; POLA1, deoxyribonucleic acid polymerase alpha; RRM1, large subunit of ribonucleotide reductase; RRM2, small subunit of ribonucleotide reductase. mRNA expression of SLC28A1 not detectable. (B) Relative protein expression of selected proteins involved in the transport and metabolism of gemcitabine in BxPC-3, MIA PaCa-2, and PANC-1. Cytidine deaminase highlighted (red rectangle). Data are displayed as means of three independent samples, and error bars are S.D. Raw data are available in Supplemental Fig. 3. cN-II, cytosolic 5′-nucleotidase II (NT5C2); cN-IIIA, cytosolic 5′-nucleotidase III A (NT5C3); dCK, deoxycytidine kinase; RRM1, large subunit of ribonucleotide reductase; RRM2, small subunit of ribonucleotide reductase. *Antibodies against transporter proteins (hCNT and hENT) not available.