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The role of Nrf2 in airway inflammation. Nrf2 can either contribute to or be protective against airway inflammation. Nrf2 has been shown to be protective in OVA-induced airway inflammation by promoting airway epithelial cell barrier function. In contrast, Nrf2 contributes to airway inflammation caused by PM2.5 through a mechanism that is thought to involve CYP2E1.
