TABLE 2.

Studies focused on the role of Nrf2 in skin allergy

Disease	Model	Effect of Nrf2-Knockout	References
Atopic Dermatitis	BALB/cWT & Nrf2 (−/−)	↓ Ear thickness; ↓ effector cell infiltration, ↓ type 2 cytokine, ↓ IgE response	(Ogawa et al., 2020b)
Contact Dermatitis	Ex vivo: BMDC Nrf2 (+/+) versus (−/−)	↓ Expression of antioxidant genes	(Mussotter et al., 2016)
	C57BL/6WT & Nrf2(−/−)	↑ PMN recruitment to skin during sensitization phase	(Helou et al., 2019)
	C57BL/6WT & Nrf2(−/−)	↑ Ear thickness	(El Ali et al., 2013; Helou et al., 2019)

IgE, immunoglobulin E.