Table 1.
Patient demographics and disease characteristics at baseline
| Characteristic | All treated patients (n = 159), n (%) |
|---|---|
| Age | |
| Median, y (range) | 60 (33-71) |
| ≥65 y | 45 (28) |
| Male | 106 (67) |
| ECOG PS | |
| 0 | 110 (69) |
| 1 | 49 (31) |
| Histology | |
| CLL | 146 (92) |
| SLL | 13 (8) |
| Rai stage | |
| 0/I/II | 113 (71) |
| III/IV | 44 (28) |
| Missing | 2 (1) |
| Bulky disease (cm) | |
| ≥5 | 48 (30) |
| ≥10 | 5 (3) |
| Cytopenia at baseline | |
| Any cytopenia | 54 (34) |
| Hemoglobin ≤11 g/dL | 37 (23) |
| Platelet count ≤100 × 109/L | 21 (13) |
| ANC ≤1.5 × 109/L | 13 (8) |
| Hierarchical cytogenetics (FISH) classification* | |
| Del(17p) | 20 (13) |
| Del(11q) | 28 (18) |
| Trisomy 12 | 23 (14) |
| Normal | 33 (21) |
| Del(13q) | 54 (34) |
| Unknown | 1 (1) |
| Mutated TP53 | |
| Yes | 16 (10) |
| No | 142 (89) |
| Unknown | 1 (1) |
| Del(17p) or mutated TP53 | |
| Yes | 27 (17) |
| No | 129 (81) |
| Unknown | 3 (2) |
| IGHV gene mutation status | |
| Unmutated | 89 (56) |
| Mutated | 66 (42) |
| Unknown | 4 (3) |
| Complex karyotype† | |
| Yes | 31 (19) |
| No | 102 (64) |
| Unknown | 26 (16) |
ANC, absolute neutrophil count; ECOG PS, Eastern Cooperative Oncology Group performance status; FISH, fluorescence in situ hybridization; MRD, minimal residual disease.
*
Per Döhner hierarchy.
†
Defined as ≥3 abnormalities by CpG-stimulated cytogenetics.