Table 1.
Clearance of Histidine-Rich Protein 2 (HRP2) in Patients Followed Longitudinally After Antimalarial Treatment in 3 Different Sites in Sub-Saharan Africa
| Variable | Angola (n = 311) | Tanzania (n = 95) | Senegal (n = 131) |
|---|---|---|---|
| Monotonically decreasing HRP2 concentrationa | 230 | 68 | 85 |
| Increase in HRP2 concentration after day 7b | 52 | 20 | 32 |
| Data from <4 time pointsc | 29 | 7 | 14 |
| Estimated clearance rate, d−1 | 0.15 (0.10–0.21) | 0.15 (0.12–0.17) | 0.23 (0.15–0.33) |
| Estimated half-life, d | 4.5 (3.3–6.6) | 4.7 (4.0–5.9) | 3.0 (2.1–4.5) |
| Estimated time to reach 1000 pg/mL, d | 40 (29–59) | 37 (31–50) | 24 (17–33) |
| Goodness of fit of first-order kinetics clearance model, R2 | 0.98 (0.96–0.99) | 0.98 (0.96–0.99) | 0.94 (0.91–0.97) |
Data are no. of participants or median value (interquartile range).
a
Within a 25% or 1000 pg/mL margin of error.
b
Indication of possible treatment failure. Data denote no. of participants who were excluded from calculation of clearance rate.
c
Data denote no. of participants who were excluded from calculation of clearance rate.