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. 2015 May 11;2015(5):CD009652. doi: 10.1002/14651858.CD009652.pub2

Comparison 1. CBT (plus taper) versus taper.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Successful discontinuation of BZDs 11   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.1 Post treatment 9 423 Risk Ratio (M‐H, Random, 95% CI) 1.40 [1.05, 1.86]
1.2 3 month follow‐up 9 460 Risk Ratio (M‐H, Random, 95% CI) 1.51 [1.15, 1.98]
1.3 6 month follow‐up 3 155 Risk Ratio (M‐H, Random, 95% CI) 1.94 [0.88, 4.30]
1.4 11/12 month follow‐up 5 284 Risk Ratio (M‐H, Random, 95% CI) 1.42 [0.89, 2.28]
1.5 15 month follow‐up 1 146 Risk Ratio (M‐H, Random, 95% CI) 0.8 [0.49, 1.31]
1.6 Follow‐up ≥ 24 months 2 73 Risk Ratio (M‐H, Random, 95% CI) 1.77 [0.98, 3.17]
2 Sensitivity analysis (Allocation concealment): successful discontinuation of BZDs 8   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
2.1 Post treatment 8 370 Risk Ratio (M‐H, Random, 95% CI) 1.50 [1.12, 2.02]
3 Sensitivity analysis (Blinding of assessor): successful discontinuation of BZDs 5   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
3.1 Post treatment 4 159 Risk Ratio (M‐H, Random, 95% CI) 1.08 [0.73, 1.59]
3.2 3 month follow‐up 4 103 Risk Ratio (M‐H, Random, 95% CI) 1.60 [1.08, 2.36]
3.3 6 month follow‐up 2 94 Risk Ratio (M‐H, Random, 95% CI) 1.98 [0.37, 10.47]
3.4 12 month follow‐up 1 62 Risk Ratio (M‐H, Random, 95% CI) 0.70 [0.28, 1.79]
3.5 Follow‐up ≥ 24 months 1 21 Risk Ratio (M‐H, Random, 95% CI) 2.73 [1.02, 7.32]
4 Reduce BZDs > 50% 4   Odds Ratio (M‐H, Random, 95% CI) Subtotals only
4.1 Post treatment 3 178 Odds Ratio (M‐H, Random, 95% CI) 0.93 [0.11, 8.18]
4.2 3 month follow‐up 2 69 Odds Ratio (M‐H, Random, 95% CI) 1.99 [0.47, 8.47]
4.3 6 month follow‐up 1 62 Odds Ratio (M‐H, Random, 95% CI) 0.76 [0.28, 2.07]
4.4 12 month follow‐up 2 125 Odds Ratio (M‐H, Random, 95% CI) 1.07 [0.14, 8.21]
5 Drop‐outs or lost to follow‐up 10   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
5.1 From 0 to post treatment follow‐up 9 478 Risk Ratio (M‐H, Random, 95% CI) 1.05 [0.66, 1.66]
5.2 From 0 to 3 month follow‐up 1 65 Risk Ratio (M‐H, Random, 95% CI) 1.71 [0.16, 17.98]
5.3 From 0 to 6 month follow‐up 1 62 Risk Ratio (M‐H, Random, 95% CI) 0.70 [0.17, 2.88]
5.4 From 0 to 12 month follow‐up 1 65 Risk Ratio (M‐H, Random, 95% CI) 2.57 [0.28, 23.44]